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Achaogen Highlights Multiple Plazomicin Presentations at ESCMID/ASM 2018 Conference
Assessment of AUC-Based Therapeutic Drug Management (TDM) Algorithms for Plazomicin Therapy in Patients with Bloodstream Infection (BSI),
Pharmacokinetic variability in critically ill patients with serious bacterial infections is a known issue. Modeling and simulations using data from the subset of Phase 3
Pharmacokinetics-Pharmacodynamics (PK-PD) of Plazomicin (PLZ) against Carbapenem-Resistant Enterobacteriaceae (CRE) in Neutropenic Murine Thigh Infection and Pneumonia Models, Louie et al. (Poster 100)
The authors analyzed data from murine infection models to identify the pharmacodynamic index and exposure intensity associated with optimized killing of CRE. The results suggest that exposures associated with a 15 mg/kg once daily dose in patients is suitable for treating CRE with a minimum inhibitory concentration (MIC) breakpoint of 4 mg/L.
Encore Presentation: Population Pharmacokinetic Analyses for Plazomicin Using Pooled Data from Phase 1, 2 and 3 Studies,
The authors developed a population pharmacokinetic model for conducting simulations and generating individual estimates of drug exposure for use in pharmacokinetic-pharmacodynamic analyses (PK-PD).
Encore Presentation: Pharmacokinetic-Pharmacodynamic Target Attainment Analyses to Support Plazomicin Dose Selection and Recommendations for Interpretive Criteria for In Vitro Susceptibility Testing for Enterobacteriaceae, Bhavnani et al. (Poster 85)
The authors concluded that the total-drug plasma AUC values associated with the plazomicin clinical dose achieved ≥90% probability of target attainment across the plazomicin MIC distribution for Enterobacteriaceae in patients with complicated urinary tract infections (cUTI), including acute pyelonephritis (AP), bloodstream infection (BSI), or hospital-acquired bacterial pneumonia (HABP)/ventilator-associated bacterial pneumonia (VABP).
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